Nicotine is addictive. It is not recommended for children and young adults, pregnant or breast-feeding women, and persons with existing medical conditions. While nicotine is not the primary cause of smoking-related diseases, the use of nicotine-containing products is not risk-free. IQOS delivers nicotine in a comparable way to cigarettes. Our clinical studies show that the amount and rate of nicotine absorbed when using one tobacco stick with IQOS is comparable to that of smoking one cigarette.